Epithalon
Preclinical ResearchAlso known as: Epitalon, Epithalamin, Ala-Glu-Asp-Gly
Educational Content Only
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The FDA has not evaluated many of the peptides discussed here. Always consult a licensed healthcare provider before making any health decisions.
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied primarily for its potential effects on telomere elongation, pineal gland function, and melatonin regulation in animal models and limited human studies.
The following areas have been examined in research contexts. This does not constitute medical advice or imply proven efficacy in humans.
- Sleep Optimization
- Anti-Aging & Longevity
Research suggests Epithalon may activate telomerase, potentially influencing telomere length. It has also been studied for effects on pineal gland melatonin synthesis and regulation of neuroendocrine aging.
Limited human data. Most research from Russian institutes in the 1980s-2000s. Study designs and methodologies vary widely.
Selected peer-reviewed papers from research literature. These are educational references only and do not imply proven efficacy or safety in humans.
- Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
Khavinson VK et al. (2003). Bulletin of Experimental Biology and Medicine.DOI: 10.1023/A:1025493705728
- Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties
Araj SK et al. (2025). International Journal of Molecular Sciences.DOI: 10.3390/ijms26062691
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Al-Dulaimi S et al. (2025). Biogerontology.DOI: 10.1007/s10522-025-10315-x
Want to learn more?
Ask Research Chat about EpithalonHalf-Life
Unknown in humans
Administration
subcutaneous injection, intravenous (in research settings)
Legal Status (US)
Research chemical in the US. Not FDA-approved.
278 indexed research passages
Related Peptides
P21 is a short synthetic peptide derived from humanin with modifications intended to enhance potency and stability. Research has examined its potential roles in neuroprotection, cognitive function, and cellular survival signaling, particularly in the context of Alzheimer's disease models and age-related cognitive decline.
Lemairamin is a plant-derived alkaloid (isolated as WGX-50 from Evodia lepta) studied in the context of neuroprotection and neurological aging. Research in animal models has examined its potential to protect neurons from amyloid-beta toxicity and oxidative stress, with interest in Alzheimer's disease research.
9-ME-BC is a synthetic β-carboline alkaloid with structural similarity to naturally occurring harman compounds. Research in animal models has examined its potential neuroprotective, dopaminergic, and pro-cognitive properties, with particular interest in its ability to promote neurogenesis and dendritic growth in dopaminergic neurons.
GHK (Glycyl-L-histidyl-L-lysine) is a naturally occurring tripeptide found in human plasma, urine, and saliva that serves as a precursor to the copper-binding complex GHK-Cu. Research has examined its potential roles in wound healing, collagen synthesis, and gene expression modulation independently of copper chelation.