MOTS-c

Preclinical Research

Also known as: Mitochondrial open reading frame of the 12S rRNA-c

Educational Content Only

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The FDA has not evaluated many of the peptides discussed here. Always consult a licensed healthcare provider before making any health decisions.

Overview

MOTS-c is a 16-amino acid mitochondria-derived peptide encoded within the 12S rRNA gene of the mitochondrial genome, identified by Chang et al. in 2015. Research has examined its roles as a metabolic regulator, exercise mimetic, and longevity signaling molecule, with studies showing effects on insulin sensitivity, fat metabolism, and healthspan in animal models.

Possible Uses

The following areas have been examined in research contexts. This does not constitute medical advice or imply proven efficacy in humans.

Muscle Recovery & Repair
Fat Loss & Metabolism
Anti-Aging & Longevity

Mechanism of Action

MOTS-c enters the nucleus in response to metabolic stress and activates AMPK-dependent gene transcription, regulating fatty acid oxidation, glucose uptake, and mitochondrial biogenesis. Research also suggests direct folate cycle and methionine metabolism interactions affecting AMPK activation.

Safety Notes

Primarily studied in animal models. Limited human pharmacological and safety data. Not FDA-approved.

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Research Profile

Half-Life

Short; minutes to hours (estimated from animal pharmacokinetics)

Administration

subcutaneous injection, intraperitoneal (animal studies)

Legal Status (US)

Research chemical. Not FDA-approved.

220 indexed research passages

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