Semax
Phase II TrialsAlso known as: Met-Glu-His-Phe-Pro-Gly-Pro
Educational Content Only
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The FDA has not evaluated many of the peptides discussed here. Always consult a licensed healthcare provider before making any health decisions.
Semax is a synthetic analogue of the ACTH 4-7 fragment, developed in Russia and studied for neuroprotective, nootropic, and neurotrophic effects. It is approved as a drug in Russia and Ukraine.
The following areas have been examined in research contexts. This does not constitute medical advice or imply proven efficacy in humans.
- Cognitive Enhancement
Research indicates Semax may increase BDNF expression in the hippocampus, modulate dopamine and serotonin receptor systems, and exhibit antioxidant effects in neural tissue. It has been studied in the context of stroke recovery in animal models and clinical settings.
Approved in Russia. Generally reported as well-tolerated. Limited long-term Western safety data.
Selected peer-reviewed papers from research literature. These are educational references only and do not imply proven efficacy or safety in humans.
- Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion
Sudarkina OY et al. (2021). International Journal of Molecular Sciences.DOI: 10.3390/ijms22126179
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Ask Research Chat about SemaxHalf-Life
~7 minutes (short; intranasal route studied)
Administration
intranasal, subcutaneous injection
Legal Status (US)
Research chemical in the US. Not FDA-approved.
162 indexed research passages
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